Higher Order Aberrations and Visual Outcomes in Wavefront-Optimized Sub-Bowman Keratomileusis: Flap Creation Using Femtosecond Laser Versus Mechanical Microkeratome

Abstract

Purpose: The aim of this study was to compare the outcomes of wavefront-optimized sub-Bowman keratomileusis (SBK) performed using the 150 KHz IntraLase femtosecond (IFS) laser (Abbot Medical Optics) with those using the Moria Evo 3 One Use-Plus SBK mechanical microkeratome (Moria SA).

Design: A prospective comparative clinical trial.

Methods: Fifty patients had bilateral wavefront-optimized SBK performed for myopia or myopic astigmatism. In 25 patients, the flap was created with the 150 KHz IFS laser (group 1) and in the other 25 with the Moria One Use-Plus SBK mechanical microkeratome (group 2). All other treatment parameters were the same. Results were reported for 1 eye per patient in each group (ie, 25 eyes in each group).

Results: Efficacy, refractive stability, predictability, and safety profiles were comparable between the 2 groups. Although higher order aberrations (HOAs) increased significantly in both groups after laser in situ keratomileusis, intergroup comparison revealed that group 1 was associated with a significantly higher induction of both total HOAs [mean root mean square (RMS), 0.63 ± 0.20 in group 1 vs 0.52 ± 0.14 in group 2; P = 0.031] and spherical aberrations (RMS, 0.37 ± 0.17 in group 1 vs 0.22 ± 0.09 in group 2; P < 0.001) as compared with group 2.

Conclusions: Flaps created using the Moria Evo 3 One Use-Plus SBK mechanical microkeratome were associated with significantly lower induction of total HOAs and spherical aberrations as compared with 150 KHz IFS flaps at the end of 3 months follow-up.