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Review
. 2015 Aug;29(4):619-40.
doi: 10.1016/j.hoc.2015.04.009.

Epidemiology and Inherited Predisposition for Sporadic Pancreatic Adenocarcinoma

Rachael Z Stolzenberg-Solomon  1 , Laufey T Amundadottir  2
Affiliations
Review

Epidemiology and Inherited Predisposition for Sporadic Pancreatic Adenocarcinoma

Rachael Z Stolzenberg-Solomon et al. Hematol Oncol Clin North Am. 2015 Aug.

Abstract

Given the changing demographics of Western populations, the numbers of pancreatic cancer cases are projected to increase during the next decade. Diabetes, recent cigarette smoking, and excess body weight are the cancer's most consistent risk factors. The search for common and rare germline variants that influence risk of pancreatic cancer through genome-wide association studies and high-throughput-sequencing-based studies is underway and holds the promise of increasing the knowledge of variants and genes that play a role in inherited susceptibility of this disease. Research reported in this review has advanced the understanding of pancreatic cancer.

Keywords: Diabetes; Etiology; Genome-wide association studies; Pancreatic cancer.

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Figures

Figure 1
Figure 1
Incidence rates for pancreatic cancer in the United States overall and by sex and race, 1992 to 2011 Surveillance, Epidemiology, and End Results (SEER) Program and the National Center for Health Statistics. http://seer.cancer.gov/faststats
Figure 2
Figure 2
Mortality rates for pancreatic cancer in the United States overall and by sex and race, 1992 to 2011 Surveillance, Epidemiology, and End Results (SEER) Program and the National Center for Health Statistics. http://seer.cancer.gov/faststats
Figure 3
Figure 3
The current landscape of inherited pancreatic cancer risk variants. Allele frequencies ranging from rare to common are shown on x-axis, and effect sizes ranging from low to high on the y-axis. The clusters represent genes with germline mutations identified through linkage, candidate gene and sequencing approaches (top left and middle) and chromosomal band locations of common susceptibility loci identified through GWAS (lower right). Genes that are mutated as part of multi cancer syndromes are listed in black, genes that influence hereditary pancreatitis are listed in green. Risk loci that are discussed in this chapter are shown in the lower right hand part of the figure and colored according to PanScan GWAS phase they were identified: PanScan I (blue), PanScan II (red) and PanScan III (purple). GWAS loci from non-European populations were not included in the figure. Figure layout was adapted from Manolio T. et.al, Nature 2009
See this image and copyright information in PMC

References

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