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. 1989 Dec;6(12):1048-51.
doi: 10.1023/a:1015930504868.

High performance liquid chromatographic (HPLC) determination of centchroman in human serum and application to single-dose pharmacokinetics

J K Paliwal  1 , R C Gupta, P K Grover, O P Asthana, J S Srivastava, S NityaNand
Affiliations

High performance liquid chromatographic (HPLC) determination of centchroman in human serum and application to single-dose pharmacokinetics

J K Paliwal et al. Pharm Res. 1989 Dec.

Abstract

A simple and sensitive (2 ng/ml) HPLC method with fluorescence detection has been developed to measure serum concentrations of centchroman, a new nonsteroidal antifertility agent. The method was sufficiently sensitive to follow the drug over 21 days in human volunteers. Pharmacokinetic parameters of centchroman were determined after a single oral dose of 60 mg (2 x 30-mg tablets) in two healthy female volunteers. Centchroman is slowly eliminated from serum, showing a biexponential disappearance curve from serum. The terminal half-life of centchroman in the two volunteers was 168 and 175 hr, respectively.

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