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Case Reports
. 2015 Jul-Aug;5(4):314-6.
doi: 10.4103/2141-9248.160187.

Candidiasis, A Rare Cause of Gastric Perforation: A Case Report and Review of Literature

F I Ukekwe  1 , C Nwajiobi  2 , M O Agbo  3 , S O Ebede  4 , A O Eni  1
Affiliations
Case Reports

Candidiasis, A Rare Cause of Gastric Perforation: A Case Report and Review of Literature

F I Ukekwe et al. Ann Med Health Sci Res. 2015 Jul-Aug.

Abstract

Fungi are unusually rare causes of gastric perforation, with most cases of gastric perforation occurring as complications of peptic ulcer disease (PUD), nonsteroidal anti-inflammatory drugs (NSAIDs) and gastric neoplasms. Here, we report the case of a 70-year-old Nigerian male who presented with severe epigastric pain, with no associated history of PUD, NSAIDs use or gastric neoplasm. An emergency exploratory laparotomy was performed and a gastric perforation was discovered and repaired. Histopathological examination of the gastric perforation edge biopsy revealed an intense Candida growth consisting of numerous fungal spores and hyphae invading and destroying the gastric wall. He was subsequently treated with fluconazole antifungal and discharged home after an uneventful postoperative period.

Keywords: Candidiasis; Fluconazole; Gastric perforation; Peritonitis; Surgical pathology.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Photomicrograph showing numerous Candida spores (S) and budding hyphae (H) in the gastric perforation edge (H and E, ×400)
Figure 2
Figure 2
Photomicrograph showing numerous Candida spores (S) and budding hyphae (H) invading and destroying adjacent gastric wall (PAS, ×400)
See this image and copyright information in PMC

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