Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jul-Aug;5(4):321-2.
doi: 10.4103/2141-9248.160183.

Cerebral Malaria Complicated by Blindness, Deafness and Extrapyramidal Tract Manifestation

Affiliations

Cerebral Malaria Complicated by Blindness, Deafness and Extrapyramidal Tract Manifestation

P C Manyike et al. Ann Med Health Sci Res. 2015 Jul-Aug.

Abstract

Cerebral malaria is a severe manifestation of a parasitic infection caused by Plasmodium falciparum. The sequelae of this disease such as blindness, deafness, loss of motor function could be emotionally traumatic and physically disabling. We, therefore, present this case of an 8-year-old boy who presented with high-grade intermittent fever associated with multiple convulsions and prolonged coma. He regained consciousness after 12 days of treatment with intravenous quinine but was found to have blindness, sensory-neural deafness and extrapyramidal sign. This extrapyramidal sign regressed following treatment with chlorpromazine. He also regained his sight and auditory function before he was discharged though not completely. This report is aimed at emphasizing these rare complications of cerebral malaria as well as reminding clinicians working in malaria endemic areas of the world on the need for early diagnosis and prompt treatment.

Keywords: Blindness; Cerebral malaria; Coma.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

References

    1. World Health Organization. WHO Malaria Report 2008. WHO/HTM/GMP/2008.1, World Health Organization. 2008
    1. Murray CJ, Rosenfeld LC, Lim SS, Andrews KG, Foreman KJ, Haring D, et al. Global malaria mortality between 1980 and 2010: A systematic analysis. Lancet. 2012;379:413–31. - PubMed
    1. Dharmeshkumar NP, Pradeep P, Surti MM, Agarwal SB. Clinical manifestations of complicated malaria: An overview. J Indian Acad Clin Med. 2003;4:323–31.
    1. Senanayake N, Román GC. Neurological complications of malaria. Southeast Asian J Trop Med Public Health. 1992;23:672–80. - PubMed
    1. Brewster DR, Kwiatkowski D, White NJ. Neurological sequelae of cerebral malaria in children. Lancet. 1990;336:1039–43. - PubMed

LinkOut - more resources