Gluten and IgA nephropathy: you are what you eat?
- PMID: 26230197
- DOI: 10.1038/ki.2015.149
Gluten and IgA nephropathy: you are what you eat?
Abstract
Although extensively studied, the relationship between dietary antigens-in particular, gluten-and IgA nephropathy remains unclear. Using a double transgenic mouse model of IgA nephropathy that expresses both human IgA1 and human CD89, Papista et al. report that a gluten-free diet protects against the development of IgA deposition and glomerular injury, and that these events occur with the introduction of dietary gluten.
Comment on
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Gluten exacerbates IgA nephropathy in humanized mice through gliadin-CD89 interaction.Kidney Int. 2015 Aug;88(2):276-85. doi: 10.1038/ki.2015.94. Epub 2015 Mar 25. Kidney Int. 2015. PMID: 25807036
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