Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Aug 1;192(3):283-94.
doi: 10.1164/rccm.201504-0756UP.

Update in Lung Cancer 2014

Avrum Spira  1 , Balazs Halmos  2 , Charles A Powell  3
Affiliations
Review

Update in Lung Cancer 2014

Avrum Spira et al. Am J Respir Crit Care Med. .

Abstract

In the past 2 years, lung cancer research and clinical care have advanced significantly. Advancements in the field have improved outcomes and promise to lead to further reductions in deaths from lung cancer, the leading cause of cancer death worldwide. These advances include identification of new molecular targets for personalized targeted therapy, validation of molecular signatures of lung cancer risk in smokers, progress in lung tumor immunotherapy, and implementation of population-based lung cancer screening with chest computed tomography in the United States. In this review, we highlight recent research in these areas and challenges for the future.

Keywords: biomarkers; chest computed tomography screening; lung cancer; lung immunotherapy; targeted therapy.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Targetable and/or potentially targetable genetic changes in (A) adenocarcinoma and (B) squamous cell carcinomas of the lung. *Gene amplification. ALK = anaplastic lymphoma kinase; DDR2 = discoidin domain receptor tyrosine kinase 2; EGFR = epidermal growth factor receptor; FGFR = fibroblast growth factor receptor; KRAS = Kirsten rat sarcoma viral oncogene homolog; MEK = mitogen-activated protein kinase kinase; MET = mesenchymal–epithelial transition factor; PDGFRA = platelet-derived growth factor receptor α; PIK3CA = phosphatidylinositol 3-kinase, catalytic, α polypeptide. Reprinted by permission from Reference .
See this image and copyright information in PMC

References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65:5–29. - PubMed
    1. Markowitz SB, Levin SM, Miller A, Morabia A. Asbestos, asbestosis, smoking, and lung cancer: new findings from the North American insulator cohort. Am J Respir Crit Care Med. 2013;188:90–96. - PubMed
    1. Pairon JC, Andujar P, Rinaldo M, Ameille J, Brochard P, Chamming’s S, Clin B, Ferretti G, Gislard A, Laurent F, et al. Asbestos exposure, pleural plaques, and the risk of death from lung cancer. Am J Respir Crit Care Med. 2014;190:1413–1420. - PubMed
    1. Raaschou-Nielsen O, Andersen ZJ, Beelen R, Samoli E, Stafoggia M, Weinmayr G, Hoffmann B, Fischer P, Nieuwenhuijsen MJ, Brunekreef B, et al. Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE) Lancet Oncol. 2013;14:813–822. - PubMed
    1. Hart JE. Invited commentary: epidemiologic studies of the impact of air pollution on lung cancer. Am J Epidemiol. 2014;179:452–454. - PubMed

Substances