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. 2015 Oct;39(10):1125-8.
doi: 10.1016/j.leukres.2015.06.014. Epub 2015 Jun 24.

Synergy of two human endogenous retroviruses in multiple myeloma

Kathrine L M Schmidt  1 , Annette J Vangsted  2 , Bettina Hansen  1 , Ulla B Vogel  3 , N Emil U Hermansen  2 , Sara B Jensen  1 , Magdalena J Laska  1 , Bjørn A Nexø  4
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Synergy of two human endogenous retroviruses in multiple myeloma

Kathrine L M Schmidt et al. Leuk Res. 2015 Oct.

Abstract

Multiple myeloma (MM) is a severe, incurable neoplasm of the plasma cells. In this study we have used genetic epidemiology to associate the risk of MM with endogenous retroviral loci in humans. We used SNP analysis on a Sequenom platform and statistical analysis in SPSS. Markers near two endogenous retroviral loci, HERV-Fc1 on chromosome X and HERV-K on chromosome 1, were associated with MM. Moreover, there was strong gene-gene interaction in relation to risk of MM. We take this as indirect confirmation of the association.

Keywords: Genetic epidemiology; Gene–gene interaction; HERV; Human endogenous retrovirus; Myelomatosis.

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