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Review
. 2015 Jul 30;162(3):478-87.
doi: 10.1016/j.cell.2015.07.022.

A Call for Systematic Research on Solute Carriers

Adrián César-Razquin  1 , Berend Snijder  1 , Tristan Frappier-Brinton  2 , Ruth Isserlin  3 , Gergely Gyimesi  4 , Xiaoyun Bai  5 , Reinhart A Reithmeier  5 , David Hepworth  6 , Matthias A Hediger  7 , Aled M Edwards  8 , Giulio Superti-Furga  9
Affiliations
Review

A Call for Systematic Research on Solute Carriers

Adrián César-Razquin et al. Cell. .

Abstract

Solute carrier (SLC) membrane transport proteins control essential physiological functions, including nutrient uptake, ion transport, and waste removal. SLCs interact with several important drugs, and a quarter of the more than 400 SLC genes are associated with human diseases. Yet, compared to other gene families of similar stature, SLCs are relatively understudied. The time is right for a systematic attack on SLC structure, specificity, and function, taking into account kinship and expression, as well as the dependencies that arise from the common metabolic space.

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