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. 2015 Jul;27(3):155-60.
doi: 10.1016/j.sdentj.2015.01.003. Epub 2015 May 27.

Combination of bone allograft, barrier membrane and doxycycline in the treatment of infrabony periodontal defects: A comparative trial

Ashish Agarwal  1 , N D Gupta  2
Affiliations

Combination of bone allograft, barrier membrane and doxycycline in the treatment of infrabony periodontal defects: A comparative trial

Ashish Agarwal et al. Saudi Dent J. 2015 Jul.

Abstract

Aim: The purpose of the present study was to compare the regenerative potential of noncontained periodontal infrabony defects treated with decalcified freeze-dried bone allograft (DFDBA) and barrier membrane with or without local doxycycline.

Methods: This study included 48 one- or two-wall infrabony defects from 24 patients (age: 30-65 years) seeking treatment for chronic periodontitis. Defects were randomly divided into two groups and were treated with a combination of DFDBA and barrier membrane, either alone (combined treatment group) or with local doxycycline (combined treatment + doxycycline group). At baseline (before surgery) and 3 and 6 months after surgery, the pocket probing depth (PPD), clinical attachment level (CAL), radiological bone fill (RBF), and alveolar height reduction (AHR) were recorded. Analysis of variance and the Newman-Keuls post hoc test were used for statistical analysis. A two-tailed p-value of less than 0.05 was considered to be statistically significant.

Results: In the combined treatment group, the PPD reduction was 2.00 ± 0.38 mm (32%), CAL gain was 1.25 ± 0.31 mm (17.9%), and RBF was 0.75 ± 0.31 mm (20.7%) after 6 months. In the combined treatment + doxycycline group, these values were 2.75 ± 0.37 mm (44%), 1.5 ± 0.27 mm (21.1%), and 1.13 ± 0.23 mm (28.1%), respectively. AHR values for the groups without and with doxycycline were 12.5% and 9.4%, respectively.

Conclusion: There was no significant difference in the regeneration of noncontained periodontal infrabony defects between groups treated with DFDBA and barrier membrane with or without doxycycline.

Keywords: Bone grafting; Doxycycline; Guided tissue regeneration.

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Figures

Figure 1
Figure 1
Pre operative pocket probing depth in DFDBA+ barrier membrane group.
Figure 2
Figure 2
Infra bony defect mesial to 2nd premolar.
Figure 3
Figure 3
Barrier membrane placement over bone graft in defect area.
Figure 4
Figure 4
Pocket probing depth after 6 months in DFDBA+ barrier membrane group.
Figure 5
Figure 5
Pre operative radiograph of DFDBA+ barrier membrane group.
Figure 6
Figure 6
Post operative radiograph of DFDBA+ barrier membrane group.
See this image and copyright information in PMC

References

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