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Review
. 2015 Jul 17:6:363.
doi: 10.3389/fimmu.2015.00363. eCollection 2015.

Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets

Enric Gutiérrez-Martínez  1 , Remi Planès  1 , Giorgio Anselmi  1 , Matthew Reynolds  1 , Shinelle Menezes  1 , Aimé Cézaire Adiko  2 , Loredana Saveanu  2 , Pierre Guermonprez  1
Affiliations
Review

Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets

Enric Gutiérrez-Martínez et al. Front Immunol. .

Abstract

Dendritic cells (DCs) have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can cross-present cell-associated antigens by MHC class I to CD8(+) T cells. There is strong in vivo evidence that the mouse XCR1(+) DCs subset acts as a key player in this process. The intracellular processes underlying cross-presentation remain controversial and several pathways have been proposed. Indeed, a wide number of studies have addressed the cellular process of cross-presentation in vitro using a variety of sources of antigen and antigen-presenting cells. Here, we review the in vivo and in vitro evidence supporting the current mechanistic models and disscuss their physiological relevance to the cross-presentation of cell-associated antigens by DCs subsets.

Keywords: MHC class I; antigen processing; cross-presentation; cross-priming; dendritic cells; phagocytosis.

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