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Review
. 2015 Aug 3:16:509-13.
doi: 10.12659/AJCR.893803.

Pancreatic Gastrointestinal Stromal Tumor after Upper Gastrointestinal Hemorrhage and Performance of Whipple Procedure: A Case Report and Literature Review

Mehmet Aziret  1 , Süleyman Çetinkünar  2 , Elife Aktaş  3 , Oktay İrkörücü  2 , İlhan Bali  4 , Hasan Erdem  2
Affiliations
Review

Pancreatic Gastrointestinal Stromal Tumor after Upper Gastrointestinal Hemorrhage and Performance of Whipple Procedure: A Case Report and Literature Review

Mehmet Aziret et al. Am J Case Rep. .

Abstract

Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal system. These types of tumors originate from any part of the tract as well as from the intestine, colon, omentum, mesentery or retroperitoneum. GIST is a rare tumor compared to other types of tumors, accounting for less than 1% of all gastrointestinal tumors.

Case report: A 56-year-old male patient was hospitalized due to an upper gastrointestinal hemorrhage and the start of abdominal pain on the same day. In the upper gastrointestinal endoscopy that was performed, a solitary mass was found in the second section of the duodenum and a blood vessel (Forrest type 2a) was seen. The extent and location of the mass was detected by abdominal tomography. After hemodynamic recovery, a Whipple procedure was performed without any complications. A subsequent histopathological examination detected a c-kit-positive (CD117) pancreatic GIST with high mitotic index.

Conclusions: The most effective treatment method for GISTs is surgical resection. In patients with a head of pancreatic GIST, the Whipple procedure can be used more safely and effectively.

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Figures

Figure 1.
Figure 1.
Pancreatic GIST with ultrasonography.
Figure 2.
Figure 2.
Pancreatic GIST in computed tomography in relation with duodenum and vasculars (arrow).
Figure 3.
Figure 3.
Whipple procedure specimen and pancreatic GIST (arrow).
Figure 4.
Figure 4.
Immunohistochemistry CD34 positivity (×200) (H&E).
Figure 5.
Figure 5.
Immunohistochemistry CD117 positivity (×200) (H&E).
Figure 6.
Figure 6.
Relation between duodenum and tumor(×40) (H&E).
Figure 7.
Figure 7.
Relation between pancreas and tumor(×40) (H&E).
See this image and copyright information in PMC

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