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Review
. 2013 Oct 23;2(4):201-13.
doi: 10.3390/jcm2040201.

Mesenchymal Stromal Cells: Updates and Therapeutic Outlook in Rheumatic Diseases

Yves-Marie Pers  1 , Christian Jorgensen  2
Affiliations
Review

Mesenchymal Stromal Cells: Updates and Therapeutic Outlook in Rheumatic Diseases

Yves-Marie Pers et al. J Clin Med. .

Abstract

Multipotent mesenchymal stromal cells or mesenchymal stem cells (MSCs) are adult stem cells exhibiting functional properties that have opened the way for cell-based clinical therapies. MSCs have been reported to exhibit immunosuppressive as well as healing properties, improving angiogenesis and preventing apoptosis or fibrosis through the secretion of paracrine mediators. This review summarizes recent progress on the clinical application of stem cells therapy in some inflammatory and degenerative rheumatic diseases. To date, most of the available data have been obtained in preclinical models and clinical efficacy needs to be evaluated through controlled randomized double-blind trials.

Keywords: autoimmune diseases; immune tolerance; mesenchymal stem cells; osteoarthritis; rheumatic diseases; rheumatoid arthritis.

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Figures

Figure 1
Figure 1
Schematic representation of mesenchymal stem cell (MSC)-based therapy via intra-articular injection in the treatment of rheumatic diseases. Through the release of trophic factors and cell contact, MSCs may act to reduce cartilage degeneration, osteophyte formation and synovial inflammation. MSCs may also have systemic properties that may be of interest in extra-articular manifestations of rheumatic diseases.
Figure 2
Figure 2
Current therapeutic applications of mesenchymal stem cells (MSCs) in rheumatic diseases.
See this image and copyright information in PMC

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