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. 2014 Jul 29;3(3):883-96.
doi: 10.3390/jcm3030883.

Health Resource Utilization Associated with Skeletal-Related Events in Patients with Advanced Prostate Cancer: A European Subgroup Analysis from an Observational, Multinational Study

Amit Bahl  1 , Herbert Hoefeler  2 , Ignacio Duran  3 , Guy Hechmati  4 , Cristina Garzon-Rodriguez  5 , John Ashcroft  6 , Vito Lorusso  7   8 , Prayashi Ghelani  9 , Rachel Wei  10 , Emma Thomas  11 , Diana Lüftner  12
Affiliations

Health Resource Utilization Associated with Skeletal-Related Events in Patients with Advanced Prostate Cancer: A European Subgroup Analysis from an Observational, Multinational Study

Amit Bahl et al. J Clin Med. .

Abstract

This study aimed to increase the understanding of health resource utilization (HRU) associated with skeletal-related events (SREs) occurring in patients with bone metastases secondary to advanced prostate cancer. A total of 120 patients from Germany, Italy, Spain and the United Kingdom were enrolled in this observational study. They had bone metastases secondary to prostate cancer and had experienced at least one SRE in the 97 days before giving informed consent. HRU data were collected retrospectively for 97 days before enrolment and prospectively for up to 18-21 months. HRU, including the number and duration of inpatient hospitalizations, number of outpatient and emergency department visits and procedures, was independently attributed by investigators to an SRE. Of the 222 SREs included in this analysis, 26% were associated with inpatient stays and the mean duration per SRE was 21.4 days (standard deviation (SD) 17.8 days). Overall, 174 SREs (78%) required an outpatient visit and the mean number of visits per SRE was 4.6 (SD 4.6). All SREs are associated with substantial HRU. Preventing SREs in patients with advanced prostate cancer and bone metastases may help to reduce the burden to both patients and European healthcare systems.

Keywords: Europe; bone metastases; health resource utilization; prostate cancer; skeletal-related events.

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Figures

Figure 1
Figure 1
Proportion of skeletal related events (SREs) requiring an inpatient stay. Data show the proportion of SREs requiring an inpatient stay versus the proportion of SREs that did not require an inpatient stay. Data for PF are shown first overall, and then by VF and NVF subcategories.
Figure 2
Figure 2
Mean duration of inpatient stays for each type of SRE and for all types of SRE combined. Data shown as mean (+standard deviation) duration of inpatient stays for SREs that required an inpatient stay. Median (Q1, Q3) values are displayed below the graph. If an SRE was associated with multiple inpatient stays, the total duration of all stays was used. Data for PF are shown first overall, and then by VF and NVF subcategories.
Figure 3
Figure 3
Mean duration of inpatient stays according to healthcare facility type, for all SREs combined. Data shown as mean (+standard deviation) duration of inpatient stays according to healthcare facility type for all SREs combined. Median (Q1, Q3) values are displayed below the graph. If an SRE was associated with multiple inpatient stays, the total duration of all related stays was used.
Figure 4
Figure 4
Proportion of SREs requiring an outpatient visit. Data show the proportion of SREs requiring an outpatient visit. Data for PF are shown first overall, and then by VF and NVF subcategories.
Figure 5
Figure 5
Mean number of outpatient visits for each type of SRE and for all types of SRE combined. Data shown as mean (+standard deviation) number of outpatient visits per SRE. Median (Q1, Q3) values are displayed below the graph. Data for PF are shown first overall, and then by VF and NVF subcategories.
Figure 6
Figure 6
Mean number of procedures for each type of SRE and for all types of SRE combined. Data shown as mean (+standard deviation) number of procedures per SRE. Median (Q1, Q3) data are displayed below the graph. Data include outpatient visits, overnight stays and emergency department visits. Data for PF are shown first overall, and then by VF and NVF subcategories.
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