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Review
. 2015 Aug 15;128(16):2957-64.
doi: 10.1242/jcs.156398. Epub 2015 Aug 3.

The Exocyst at a Glance

Bin Wu  1 , Wei Guo  2
Affiliations
Review

The Exocyst at a Glance

Bin Wu et al. J Cell Sci. .

Abstract

The exocyst is an octameric protein complex that is implicated in the tethering of secretory vesicles to the plasma membrane prior to SNARE-mediated fusion. Spatial and temporal control of exocytosis through the exocyst has a crucial role in a number of physiological processes, such as morphogenesis, cell cycle progression, primary ciliogenesis, cell migration and tumor invasion. In this Cell Science at a Glance poster article, we summarize recent works on the molecular organization, function and regulation of the exocyst complex, as they provide rationales to the involvement of this complex in such a diverse array of cellular processes.

Keywords: Exocyst; Membrane fusion; Rab; Ral; Rho; Vesicle tether.

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Conflict of interest statement

Competing interests

The authors declare no competing or financial interests.

References

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