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Multicenter Study
. 2016 Jan;18(1):96-104.
doi: 10.1093/neuonc/nov145. Epub 2015 Aug 4.

Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection

Florian Ringel  1 , Haiko Pape  1 , Michael Sabel  1 , Dietmar Krex  1 , Hans Christoph Bock  1 , Martin Misch  1 , Astrid Weyerbrock  1 , Thomas Westermaier  1 , Christian Senft  1 , Philippe Schucht  1 , Bernhard Meyer  1 , Matthias Simon  1 ; SN1 study group
Collaborators, Affiliations
Multicenter Study

Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection

Florian Ringel et al. Neuro Oncol. 2016 Jan.

Abstract

Background: While standards for the treatment of newly diagnosed glioblastomas exist, therapeutic regimens for tumor recurrence remain mostly individualized. The role of a surgical resection of recurrent glioblastomas remains largely unclear at present. This study aimed to assess the effect of repeated resection of recurrent glioblastomas on patient survival.

Methods: In a multicenter retrospective-design study, patients with primary glioblastomas undergoing repeat resections for recurrent tumors were evaluated for factors affecting survival. Age, Karnofsky performance status (KPS), extent of resection (EOR), tumor location, and complications were assessed.

Results: Five hundred and three patients (initially diagnosed between 2006 and 2010) undergoing resections for recurrent glioblastoma at 20 institutions were included in the study. The patients' median overall survival after initial diagnosis was 25.0 months and 11.9 months after first re-resection. The following parameters were found to influence survival significantly after first re-resection: preoperative and postoperative KPS, EOR of first re-resection, and chemotherapy after first re-resection. The rate of permanent new deficits after first re-resection was 8%.

Conclusion: The present study supports the view that surgical resections of recurrent glioblastomas may help to prolong patient survival at an acceptable complication rate.

Keywords: glioblastoma; overall survival; recurrent tumor; surgical resection.

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Figures

Fig. 1.
Fig. 1.
Influence of extent of resection at initial surgery and first re-resection on survival.
Fig. 2.
Fig. 2.
Kaplan Meier survival analysis after first re-resection depending on adjuvant therapy after first re-resection.
Fig. 3.
Fig. 3.
Conservative (left) and explorative (right) classification and regression tree model of factors influencing survival after first re-resection. Median overall survivals are given in the respective Kaplan Maier plots.
See this image and copyright information in PMC

References

    1. Stupp R, Mason WP, van den Bent MJ et al. . Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352(10):987–996. - PubMed
    1. Weller M, Cloughesy T, Perry JR et al. . Standards of care for treatment of recurrent glioblastoma–are we there yet? Neuro Oncol. 2013;15(1):4–27. - PMC - PubMed
    1. Combs SE, Thilmann C, Edler L et al. . Efficacy of fractionated stereotactic reirradiation in recurrent gliomas: long-term results in 172 patients treated in a single institution. J Clin Oncol. 2005;23(34):8863–8869. - PubMed
    1. Patel M, Siddiqui F, Jin JY et al. . Salvage reirradiation for recurrent glioblastoma with radiosurgery: radiographic response and improved survival. J Neurooncol. 2009;92(2):185–191. - PubMed
    1. Vordermark D, Kolbl O, Ruprecht K et al. . Hypofractionated stereotactic re-irradiation: treatment option in recurrent malignant glioma. BMC Cancer. 2005;5:55. - PMC - PubMed

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