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Comment
. 2015 Aug;5(8):796-8.
doi: 10.1158/2159-8290.CD-15-0739.

Clonal evolution: multiregion sequencing of esophageal adenocarcinoma before and after chemotherapy

Siddhartha Devarakonda  1 , Ramaswamy Govindan  2
Affiliations
Comment

Clonal evolution: multiregion sequencing of esophageal adenocarcinoma before and after chemotherapy

Siddhartha Devarakonda et al. Cancer Discov. 2015 Aug.

Abstract

It is possible to decipher the clonal architecture of a tumor and the sequence in which cancer clones acquire genomic alterations through multiregion sequencing (M-seq). Serial evaluation of tumor specimens through M-seq can provide valuable information on the molecular basis of resistance to therapy.

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