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. 2015 Jul 19:8:55-62.
doi: 10.4137/CMED.S27700. eCollection 2015.

Androgen Deficiency and Erectile Dysfunction in Patients with Type 2 Diabetes

Entesar Oa El Saghier  1 , Salah E Shebl  2 , Olfat A Fawzy  1 , Ihab M Eltayeb  3 , Lamya Ma Bekhet  4 , Abdelnasser Gharib  5
Affiliations

Androgen Deficiency and Erectile Dysfunction in Patients with Type 2 Diabetes

Entesar Oa El Saghier et al. Clin Med Insights Endocrinol Diabetes. .

Abstract

Background: The association between type 2 diabetes mellitus (T2DM) and low total serum testosterone (LST) has been identified in several cross-sectional studies.

Objectives: To assess the prevalence of androgen deficiency and erectile dysfunction (ED) and their relation to glycemic control within a sample of Egyptian men with T2DM.

Research design and methods: A cross-sectional study including 70 men having T2DM. Their ages ranged from 30 to 50 years. They were evaluated for symptoms of androgen deficiency and ED, using a validated Arabic-translated Androgen Deficiency in Aging Males questionnaire and five-items version of the International Index of Erectile Function-5, respectively. Total testosterone (TT), glycated hemoglobin (HbA1c), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin were measured for all study subjects. Penile hemodynamics was assessed using penile duplex study for subjects who gave history of ED.

Results: LST was found in 40% of studied men, and 92.9% of them reported overt symptoms of androgen deficiency. ED was detected in 85.7% of those with LST, as opposed to 31.0% of those with normal TT (P < 0.000). TT was lower in diabetic men with ED compared to those without ED (12.04 ± 5.36 vs 17.11 ± 7.11 nmol/L, P < 0.001). Significant negative correlation was found between TT and age, body mass index, waist circumference, systolic and diastolic blood pressures, and HBA1c (P < 0.00). FSH, LH, and prolactin levels were within the normal reference range in all subjects. HbA1c was higher in patients who had LST with ED, compared to those with normal TT and without ED. However, multivariate logistic regression analysis did not reveal a significant association between HBA1c and LST levels.

Conclusion: LST, symptoms of androgen deficiency, and ED are common in the studied sample of Egyptian men with T2DM. Inappropriately normal FSH and LH in face of LST may denote a state of hypogonadotropic hypogonadism. HBA1c was found to be more significantly associated with ED than with LST.

Keywords: androgen; diabetes; erectile dysfunction.

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References

    1. Grossmann M, Wu FC. Male androgen deficiency: a multisystem syndrome. Asian J Androl. 2014;16(2):159–160. - PMC - PubMed
    1. Lunenfeld B, Mskhalaya G, Kalinchenko SY. Recommendations on the diagnosis, treatment and monitoring of late-onset hypogonadism in men—a suggested update. Aging Male. 2013;16(4):143–150. - PubMed
    1. Hackett GM, Kirby MAJ, Sinclair AJ. Testosterone deficiency, cardiac health, and older men. Int J Endocrinol. 2014;2014:10. Article ID 143763. - PMC - PubMed
    1. Al Hayek AA, Khader YS, Jafal S, Khawaja N, Robert AA, Ajlouni K. Prevalence of low testosterone levels in men with type 2 diabetes mellitus: a cross-sectional study. J Family Community Med. 2013;20(3):179–186. - PMC - PubMed
    1. Chueh KS, Huang SP, Lee YC, et al. The comparison of the aging male symptoms (AMS) and androgen deficiency in the aging male (ADM) questionnaire to detect androgen difiency in middle-aged men. J Androl. 2012;33(5):817–823. - PubMed

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