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. 1989 Oct;53(4):375-80.
doi: 10.1111/j.1469-1809.1989.tb01805.x.

Analysing rearrangement breakpoint distributions by means of binomial confidence intervals

K Vasarhelyi  1 , J M Friedman
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Analysing rearrangement breakpoint distributions by means of binomial confidence intervals

K Vasarhelyi et al. Ann Hum Genet. 1989 Oct.

Abstract

Non-randomness in the distribution of rearrangement breakpoints can be assessed by means of a binomial probability model. Using the binomial model, we compute confidence intervals for the observed number of breakpoints in chromosome bands and use these confidence intervals to test for non-randomness in a set of 452 constitutional rearrangement breakpoints. This method is useful because it describes the observed data and is not dependent on comparison with a pre-existing hypothesis regarding the distribution.

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