Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2015 Aug 4;22(2):197-8.
doi: 10.1016/j.cmet.2015.07.014.

Segregation of Clock and Non-Clock Regulatory Functions of REV-ERB

Andrew A Butler  1 , Thomas P Burris  2
Affiliations
Comment

Segregation of Clock and Non-Clock Regulatory Functions of REV-ERB

Andrew A Butler et al. Cell Metab. .

Abstract

The molecular clock is a master controller of circadian cellular processes that affect growth, metabolic homeostasis, and behavior. A report in Science by Zhang et al. (2015) redefines our understanding of how Rev-erba acts as an internal feedback inhibitor that modulates activity of the core clock while simultaneously regulating tissue-specific metabolic processes.

PubMed Disclaimer

Comment on

References

    1. Banerjee S, Wang Y, Solt LA, Griffett K, Kazantzis M, Amador A, El-Gendy BM, Huitron-Resendiz S, Roberts AJ, Shin Y, et al. Nat. Commun. 2014;5:5759. - PMC - PubMed
    1. Jin L, Martynowski D, Zheng S, Wada T, Xie W, Li Y. Mol. Endocrinol. 2010;24:923–929. - PMC - PubMed
    1. Kallen JA, Schlaeppi JM, Bitsch F, Geisse S, Geiser M, Delhon I, Fournier B. Structure. 2002;10:1697–1707. - PubMed
    1. Kojetin DJ, Burris TP. Nat. Rev. Drug Discov. 2014;13:197–216. - PMC - PubMed
    1. Raghuram S, Stayrook KR, Huang P, Rogers PM, Nosie AK, McClure DB, Burris LL, Khorasanizadeh S, Burris TP, Rastinejad F. Nat. Struct. Mol. Biol. 2007;14:1207–1213. - PMC - PubMed

MeSH terms

Substances

LinkOut - more resources