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. 2015 Dec;53(12):3876-80.
doi: 10.1128/JCM.01824-15. Epub 2015 Aug 5.

Lab-on-Chip-Based Platform for Fast Molecular Diagnosis of Multidrug-Resistant Tuberculosis

Andrea M Cabibbe  1 , Paolo Miotto  1 , Raquel Moure  2 , Fernando Alcaide  2 , Silke Feuerriegel  3 , Gianni Pozzi  4 , Vladislav Nikolayevskyy  5 , Francis Drobniewski  5 , Stefan Niemann  3 , Klaus Reither  6 , Daniela M Cirillo  7 ; TM-REST Consortium; TB-CHILD Consortium
Collaborators, Affiliations

Lab-on-Chip-Based Platform for Fast Molecular Diagnosis of Multidrug-Resistant Tuberculosis

Andrea M Cabibbe et al. J Clin Microbiol. 2015 Dec.

Abstract

We evaluated the performance of the molecular lab-on-chip-based VerePLEX Biosystem for detection of multidrug-resistant tuberculosis (MDR-TB), obtaining a diagnostic accuracy of more than 97.8% compared to sequencing and MTBDRplus assay for Mycobacterium tuberculosis complex and rifampin and isoniazid resistance detection on clinical isolates and smear-positive specimens. The speed, user-friendly interface, and versatility make it suitable for routine laboratory use.

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References

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