Associations between low levels of serum uric acid and cardiometabolic parameters

Abstract

Introduction: Elevated serum uric acid (SUA) levels are associated with increased cardiovascular risk.

Objective: To evaluate the association between SUA levels and cardiometabolic parameters.

Materials and methods: SUA levels and metabolic parameters were evaluated in 139 subjects, divided into low (<5 mg/dl) and high SUA group (≥5 mg/dl).

Results: In low SUA group, SUA levels directly correlated with creatinine, body mass index, waist circumference, blood pressure, glucose and insulin levels, triglyceride and C-reactive protein levels. In high SUA group, SUA levels directly correlated with body weight, triglyceride, C-reactive protein, and inversely correlated with HDL-cholesterol concentrations.

Discussion and conclusions: High SUA levels were linked with several cardiometabolic parameters, and low SUA levels were linearly correlated with recognized cardiovascular risk factors. Therefore, increasing SUA levels - even at low concentration - could be associated with higher cardiovascular risk. Thus the range of normality for SUA level should be further analysed.

Keywords: Cardiovascular risk; range of normality; uric acid.