doi: 10.1016/j.apradiso.2015.07.003.
Epub 2015 Jul 17.
Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), β-amyloid PET imaging tracer for Alzheimer's disease diagnosis
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- PMID: 26248085
- DOI: 10.1016/j.apradiso.2015.07.003
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Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), β-amyloid PET imaging tracer for Alzheimer's disease diagnosis
Appl Radiat Isot.
2015 Nov.
Abstract
[11C]PIB is the most used amyloid plaques-specific positron-emitting radiotracers. The radiosynthesis of this compound, carried out by methylation of its precursor with [11C]methyl triflate in 2-butanone, has been improved optimizing the initial concentration and the purification method. Two HPLC methods were compared: good radiochemical yields, specific activities, and chemical purity above 98% were achieved by using as eluant acetonitrile/citrate and formulation in 10% ethanol.
Keywords: Alzheimer's disease; Cyclotron; [11C]MeOTf; [11C]PIB; β-amyloid.
Copyright © 2015 Elsevier Ltd. All rights reserved.
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