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. 2015 Sep 15;25(18):3966-9.
doi: 10.1016/j.bmcl.2015.07.028. Epub 2015 Jul 17.

Synergistic activation of quorum sensing in Vibrio harveyi

Aviad Mandabi  1 , Hadas Ganin  1 , Michael M Meijler  2
Affiliations

Synergistic activation of quorum sensing in Vibrio harveyi

Aviad Mandabi et al. Bioorg Med Chem Lett. .

Abstract

Autoinducer-2 (AI-2) has been suggested to serve as a ubiquitous quorum sensing (QS) signal that mediates intra- and interspecies cross-talk between bacteria. To add tools for the study of its function in bacterial communication, we present a new and an improved synthetic route to AI-2 and aromatic analogues. We used this strategy to prepare naphthyl-DPD, and observed remarkably high synergistic activity at low nanomolar concentrations for this analogue in Vibrio harveyi.

Keywords: AI-2; DPD; Quorum sensing; V. harveyi.

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