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Comment
. 2015 Aug;2(8):677-679.
doi: 10.1016/S2215-0366(15)00236-9.

Brain disease model of addiction: why is it so controversial?

Nora D Volkow  1 , George Koob  2
Affiliations
Comment

Brain disease model of addiction: why is it so controversial?

Nora D Volkow et al. Lancet Psychiatry. 2015 Aug.
No abstract available

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Figures

Figure 1
Figure 1
Conceptual Framework for Neurobiological Bases of the Transition to Substance Use Disorders
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References

    1. Hall W, Carter A, Forlini C. The brain disease model of addiction: is it supported by the evidence and has it delivered on its promises? The Lancet Psychiatry. 2015;2(1):105–10. - PubMed
    1. Kalivas PW, Volkow ND. New medications for drug addiction hiding in glutamatergic neuroplasticity. Mol Psychiatry. 2011;16(10):974–86. - PMC - PubMed
    1. Koob GF, Zorrilla EP. Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor. Curr Opin Investig Drugs. 2010;11(1):63–71. - PMC - PubMed
    1. Conti CL, Moscon JA, Fregni F, Nitsche MA, Nakamura-Palacios EM. Cognitive related electrophysiological changes induced by non-invasive cortical electrical stimulation in crack-cocaine addiction. Int J Neuropsychopharmacol. 2014;17(9):1465–75. - PubMed
    1. Dinur-Klein L, Dannon P, Hadar A, et al. Smoking cessation induced by deep repetitive transcranial magnetic stimulation of the prefrontal and insular cortices: a prospective, randomized controlled trial. Biol Psychiatry. 2014;76(9):742–9. - PubMed