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Review
. 2015 Sep;26(9):449-50.
doi: 10.1016/j.tem.2015.07.005. Epub 2015 Aug 4.

Macrophages decide between regeneration and fibrosis in muscle

Pura Muñoz-Cánoves  1 , Antonio L Serrano  2
Affiliations
Review

Macrophages decide between regeneration and fibrosis in muscle

Pura Muñoz-Cánoves et al. Trends Endocrinol Metab. 2015 Sep.

Abstract

Defective muscle regeneration is usually accompanied by excessive matrix accumulation (fibrosis). A recent study reveals how this fibrotic process is prevented to allow successful regeneration, through a timely interplay between macrophages and fibro/adipogenic progenitor cells. This has biomedical relevance for fibrotic muscular dystrophies.

Keywords: fibro/adipogenic progenitors; fibrosis; macrophages; nilotinib; regeneration.

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