Interleukin-6 in CLL: accelerator or brake?
- PMID: 26251223
- DOI: 10.1182/blood-2015-06-650804
Interleukin-6 in CLL: accelerator or brake?
Abstract
In this issue of Blood, Li et al provide insight into the interactions between immunoreceptor signals in a human cancer microenvironment presenting a novel mechanism by which microenvironment-produced interleukin (IL)-6 acts as a tumor suppressor in chronic lymphocytic leukemia (CLL) by inhibiting toll-like receptor (TLR) signaling.
Comment on
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Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A.Blood. 2015 Aug 6;126(6):766-78. doi: 10.1182/blood-2014-12-618678. Epub 2015 Jun 3. Blood. 2015. PMID: 26041742
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