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Review
. 2015 Sep;7(9):667-71.
doi: 10.14740/jocmr2261w. Epub 2015 Jul 24.

Do Biliary Salts Have Role on Acute Kidney Injury Development?

Thiago Gomes Romano  1 , Jose Mauro Vieira Junior  2
Affiliations
Review

Do Biliary Salts Have Role on Acute Kidney Injury Development?

Thiago Gomes Romano et al. J Clin Med Res. 2015 Sep.

Abstract

Acute kidney injury (AKI) is a major complication in patients with acute liver failure and chronic liver disease. Hemodynamic changes appear to be the principal alterations in these conditions, therefore there should be no known structural abnormalities responsible for AKI. On the other hand, several authors have published data on structural changes known as bile cast nephropathy or cholemic nephrosis, which basically consist of the presence of bile casts in tubular lumen analogous to those observed in myeloma. Although these findings are well documented, there is a lack of reproducibility by other authors. This paper aims to discuss, through evidence-based medical literature, the role of biliary salts on kidney injury development.

Keywords: Acute kidney injury; Bile cast; Nephropathy.

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