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. 2015 Nov;43(11):1178-83.
doi: 10.1016/j.ajic.2015.06.023. Epub 2015 Aug 4.

Microbiologic characteristics and predictors of mortality in bloodstream infections in intensive care unit patients: A 1-year, large, prospective surveillance study in 5 Italian hospitals

Diego Delle Rose  1 , Pasquale Sordillo  2 , Sabina Gini  2 , Carlotta Cerva  2 , Stefano Boros  3 , Giovanni Rezza  3 , Marcello Meledandri  4 , Maria Teresa Gallo  5 , Grazia Prignano  5 , Roberta Caccese  6 , Mario D'Ambrosio  6 , Giorgia Citterio  7 , Monica Rocco  7 , Francesca Leonardis  8 , Silvia Natoli  8 , Carla Fontana  9 , Marco Favaro  9 , Maria Grazia Celeste  10 , Tiziana Franci  11 , Gian Piero Testore  2 , Massimo Andreoni  2 , Loredana Sarmati  2
Affiliations

Microbiologic characteristics and predictors of mortality in bloodstream infections in intensive care unit patients: A 1-year, large, prospective surveillance study in 5 Italian hospitals

Diego Delle Rose et al. Am J Infect Control. 2015 Nov.

Abstract

Background: Bloodstream infections (BSIs) from multidrug-resistant (MDR) bacteria cause morbidity and mortality in intensive care unit (ICU) patients worldwide. This study investigated the incidence of BSIs in 5 adult general ICUs in Rome, Italy, and evaluated the mortality rate and risk factors associated with these infections.

Methods: Over a 12-month period, 1,318 patients were enrolled. Demographic characteristics, Simplified Acute Physiology Score II (SAPS II), comorbidities, and BSI isolate data were collected. After stratification for the outcome, statistical analysis was performed to assess the impact of patient risk factors on in-hospital mortality.

Results: There were 324 BSIs in 175 patients recorded, with an in-hospital mortality rate of 46%. Univariate analysis revealed that SAPS II, cardiac comorbidity, and Klebsiella pneumoniae BSI were significantly associated with a higher risk of death. Having a K pneumoniae BSI and cardiac illness at admission were both confirmed to be associated with death by multivariate analysis (P = .0162 and P = .0158, respectively). Most of the K pneumoniae isolates showed high resistance rates to carbapenems.

Conclusion: BSIs caused by K pneumoniae and cardiovascular comorbidity in ICU patients are associated with a higher risk of death. Thorough surveillance for MDR pathogens and stratification of the patients' risk on admission into the ICU are key to improving the outcomes of these infections.

Keywords: Bloodstream infections; Intensive care unit; Klebsiella pneumoniae; Microbiology; Mortality; Predictors.

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