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Review
. 2015 May;6(3):363-73.
doi: 10.1016/j.jare.2014.10.006. Epub 2014 Nov 1.

A mini-review on Biginelli adducts with notable pharmacological properties

Ângelo de Fátima  1 , Taniris C Braga  1 , Leonardo da S Neto  1 , Bruna S Terra  1 , Breno G F Oliveira  1 , Daniel L da Silva  1 , Luzia V Modolo  2
Affiliations
Review

A mini-review on Biginelli adducts with notable pharmacological properties

Ângelo de Fátima et al. J Adv Res. 2015 May.

Abstract

Since the disclosure of Biginelli reaction by the chemist Pietro Biginelli, functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) have emerged as prototypes for the design of compounds with a broad variety of biological activities. This mini-review describes over 100 Biginelli adducts demonstrated to be promising anticancer, inhibitors of calcium channel, anti-inflammatory, antimicrobial and antioxidant agents. Thus, this compilation presents the most notable in vitro and in vivo results for such fascinating class of organic compounds.

Keywords: Antimicrobial activity; Antioxidants; Antiproliferative activity cancer; Biginelli adducts; Calcium channel.

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Figures

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Graphical abstract
Fig. 1
Fig. 1
Basic structure of Biginelli adducts.
Fig. 2
Fig. 2
Example of Biginelli adducts that possess antiproliferative activity against cancer cells.
Fig. 3
Fig. 3
Other examples of Biginelli adducts well-known for their ability to inhibit cancer cells growth.
Fig. 4
Fig. 4
Example of Biginelli adducts that exhibit inhibitory effect on calcium channels.
Fig. 5
Fig. 5
Example of Biginelli adducts that exhibit anti-inflammatory effect.
Fig. 6
Fig. 6
Example of Biginelli adducts that exhibit antimicrobial activity.
Fig. 7
Fig. 7
Example of Biginelli adducts with ability to scavenge oxygen and/or nitrogen reactive species.
None
See this image and copyright information in PMC

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