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Review
. 2015;2(3):128-135.
doi: 10.1007/s40475-015-0051-1.

Drug Resistance in the Microaerophilic Parasite Giardia lamblia

David Leitsch  1
Affiliations
Review

Drug Resistance in the Microaerophilic Parasite Giardia lamblia

David Leitsch. Curr Trop Med Rep. 2015.

Abstract

The microaerophilic parasite Giardia lamblia is a causative agent of dysentery affecting hundreds of millions of people around the globe every year. The symptoms of the disease, commonly referred to as giardiasis, are diarrhea, nausea, and malabsorption. Treatment of giardiasis is exclusively based on chemotherapy with antigiardial drugs, including metronidazole, albendazole, and nitazoxanide. In this review, all drugs currently used in the treatment of Giardia infections are discussed with a special emphasis on treatment failure and drug resistance.

Keywords: Chemotherapy; Drug resistance; Dysentery; Giardia lamblia.

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Figures

Fig. 1
Fig. 1
Antigiardial drugs: metronidazole (1), albendazole (2), furazolidone (3), nitazoxanide (4), paromomycin (5), and bacitracin (6). All images are taken from wikipedia.org
See this image and copyright information in PMC

References

    1. Buret AG. Pathophysiology of enteric infections with Giardia duodenalis. Parasite. 2008;15:261–5. doi: 10.1051/parasite/2008153261. - DOI - PubMed
    1. Farthing MJ. Giardiasis. J Pediatr Gastroenterol Nutr. 1997;24:79–88. doi: 10.1097/00005176-199701000-00018. - DOI - PubMed
    1. Halliez MC, Buret AG. Extra-intestinal and long term consequences of Giardia duodenalis infections. World J Gastroenterol. 2013;19:8974–85. doi: 10.3748/wjg.v19.i47.8974. - DOI - PMC - PubMed
    1. Centers for Disease Control and Prevention. Parasites—Giardia. http://www.cdc.gov/parasites/giardia. Accessed April 10 2015.
    1. Tejman-Yarden N, Miyamoto Y, Leitsch D, Santini J, Debnath A, Gut J, et al. Auranofin, a reprofiled drug, is effective against metronidazole-resistant Giardia lamblia. Antimicrob Agents Chemother. 2013;57:2029–35. doi: 10.1128/AAC.01675-12. - DOI - PMC - PubMed

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