Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015;6(5):257-61.
doi: 10.1080/21655979.2015.1081320. Epub 2015 Aug 11.

Bioengineering for Organ Transplantation: Progress and Challenges

Ted Welman  1 , Sebastian Michel  2 , Nicholas Segaren  3 , Kumaran Shanmugarajah  4
Affiliations
Review

Bioengineering for Organ Transplantation: Progress and Challenges

Ted Welman et al. Bioengineered. 2015.

Abstract

Organ transplantation can offer a curative option for patients with end stage organ failure. Unfortunately the treatment is severely limited by the availability of donor organs. Organ bioengineering could provide a solution to the worldwide critical organ shortage. The majority of protocols to date have employed the use of decellularization-recellularization technology of naturally occurring tissues and organs with promising results in heart, lung, liver, pancreas, intestine and kidney engineering. Successful decellularization has provided researchers with suitable scaffolds to attempt cell reseeding. Future work will need to focus on the optimization of organ specific recellularization techniques before organ bioengineering can become clinically translatable. This review will examine the current progress in organ bioengineering and highlight future challenges in the field.

Keywords: bioengineering; decellularization; organ transplantation; recellularization; regenerative medicine.

PubMed Disclaimer

References

    1. UNetsm [database online] The Organ Procurement and Transplantation Network. Available at http://optn.transplant.hrsa.gov. Accessed 08May, 2015
    1. Orlando G, Soker S, Stratta RJ, Atala A. Will regenerative medicine replace transplantation? Cold Spring Harb Perspect Med 2013; 3(8):a015693; PMID:23906883; http://dx.doi.org/10.1101/cshperspect.a015693 - DOI - PMC - PubMed
    1. Orlando G, Wood KJ, Soker S, Stratta RJ. How regenerative medicine may contribute to the achievement of an immunosuppression-free state. Transplantation 2011; 92:e36-8; author reply e39; PMID:21989270; http://dx.doi.org/10.1097/TP.0b013e31822f59d8 - DOI - PubMed
    1. Macchiarini P, Walles T, Biancosino C, Mertsching H. First human transplantation of a bioengineered airway tissue. J Thorac Cardiovasc Surg 2004; 128:638-41; PMID:15457176; http://dx.doi.org/10.1016/j.jtcvs.2004.02.042 - DOI - PubMed
    1. L'Heureux N, Dusserre N, Konig G, Victor B, Keire P, Wight TN, Chronos NA, Kyles AE, Gregory CR, Hoyt G, et al.. Human tissue-engineered blood vessels for adult arterial revascularization. Nat Med 2006; 12:361-5; PMID:16491087; http://dx.doi.org/10.1038/nm1364 - DOI - PMC - PubMed

MeSH terms