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. 2015 Dec 1;107(Pt A):25-31.
doi: 10.1016/j.toxicon.2015.08.002. Epub 2015 Aug 8.

Structure of the BoNT/A1--receptor complex

Roger M Benoit  1 , Daniel Frey  1 , Mara M Wieser  1 , Katherine M Thieltges  1 , Rolf Jaussi  1 , Guido Capitani  1 , Richard A Kammerer  2
Affiliations

Structure of the BoNT/A1--receptor complex

Roger M Benoit et al. Toxicon. .

Abstract

Botulinum neurotoxin A causes botulism but is also used for medical and cosmetic applications. A detailed molecular understanding of BoNT/A--host receptor interactions is therefore fundamental for improving current clinical applications and for developing new medical strategies targeting human disorders. Towards this end, we recently solved an X-ray crystal structure of BoNT/A1 in complex with its neuronal protein receptor SV2C. Based on our findings, we discuss the potential implications for BoNT/A function.

Keywords: BoNT/A; SV2C; Subtype; X-ray crystallography.

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