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Review
. 2015 Jun 1;8(6):7565-9.
eCollection 2015.

Brunner's gland adenoma of duodenum: report of two cases

Li Lu  1 , Ruotong Li  1 , Guojing Zhang  1 , Zhicheng Zhao  1 , Weihua Fu  1 , Weidong Li  1
Affiliations
Review

Brunner's gland adenoma of duodenum: report of two cases

Li Lu et al. Int J Clin Exp Pathol. .

Abstract

Brunner's gland adenoma is a rare tumor of the duodenum and might also be an unusual cause of gastrointestinal bleeding or obstruction. The pathogenesis of Brunner gland hamartoma of the duodenum is unknown. We report two cases of Brunner's gland adenoma. Surgical resection was carried out because the tumor size was big in both cases and one accompanied with bleeding. Pathological examination revealed submucosal nodular hyperplasia of the Brunner's glands.

Keywords: Brunner’s gland; adenoma; duodenum.

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Figures

Figure 1
Figure 1
A. on upper endoscopy, a 2.5 cm large, pedunculated, polypoid mass with ulcerated crater was found in the first portion of the duodenum. B. EUS showed that tumor was originated from muscular is propria. C, D. Contrast-enhanced computed tomography scan showed a polypoid mass arising from the first portion of the duodenum, extending about 5 cm in length to the second portion.
Figure 2
Figure 2
A. A photograph of operation field demonstrate a lesion in duodenum, measuring it’s length approximately 7 cm. B. The gross surgical specimen showed a large duodenal lesion measuring 7.3×3.4×2.9 cm. C. Pathological examination revealed packed Brunner’s glands and ducts admixed with smooth muscle.
Figure 3
Figure 3
A. upper endoscopy showed the base of the mass related with the papilla. Pathological examination revealed. B. Gland hyperproliferation extending beyond muscolaris mucosae reaching lower portion of duodenal villi with irregular and squat profile of crowded architecture and features consistent with a Brunner’s gland hamartoma.
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