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Comment
. 2015 Jun 1;8(6):7617-8.
eCollection 2015.

Comments on Bu et al. "P16(INK₄a) overexpression and survival in osteosarcoma patients: a meta analysis"

Ming-Ming Yan  1 , Jiang-Dong Ni  1
Affiliations
Comment

Comments on Bu et al. "P16(INK₄a) overexpression and survival in osteosarcoma patients: a meta analysis"

Ming-Ming Yan et al. Int J Clin Exp Pathol. .

Abstract

Recently, we read the article "P16(INK4a) overexpression and survival in osteosarcoma patients: a meta analysis" by Jie Bu and his colleagues, published in the recent issue of International Journal Of Experimental Pathology. This research performed a meta-analysis to uncover the role of P16(INK4a) expression in overall survival rate in patients with osteosarcoma. The investigators concluded as follows: (i) the pateints with overexpression of P16(INK4a) had a longer overall survival rate than that with loss expression of P16(INK4a); (ii) P16(INK4a) was an effective biomarker of prognosis in patients with osteosarcoma.The findings are valubale and encouraging. However, some flaws and imperfections rooted in this work.

Keywords: Osteosarcoma; P16INK4a; meta-analysis.

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References

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