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Review
. 2015 Oct;20(5):506-14.
doi: 10.1097/MOT.0000000000000232.

Primary graft dysfunction: lessons learned about the first 72 h after lung transplantation

Mary K Porteous  1 , Joshua M Diamond, Jason D Christie
Affiliations
Review

Primary graft dysfunction: lessons learned about the first 72 h after lung transplantation

Mary K Porteous et al. Curr Opin Organ Transplant. 2015 Oct.

Abstract

Purpose of review: In 2005, the International Society for Heart and Lung Transplantation published a standardized definition of primary graft dysfunction (PGD), facilitating new knowledge on this form of acute lung injury that occurs within 72 h of lung transplantation. PGD continues to be associated with significant morbidity and mortality. This article will summarize the current literature on the epidemiology of PGD, pathogenesis, risk factors, and preventive and treatment strategies.

Recent findings: Since 2011, several manuscripts have been published that provide insight into the clinical risk factors and pathogenesis of PGD. In addition, several transplant centers have explored preventive and treatment strategies for PGD, including the use of extracorporeal strategies. More recently, results from several trials assessing the role of extracorporeal lung perfusion may allow for much-needed expansion of the donor pool, without raising PGD rates.

Summary: This article will highlight the current state of the science regarding PGD, focusing on recent advances, and set a framework for future preventive and treatment strategies.

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References

    1. Christie JD, Bellamy S, Ware LB, et al. Construct validity of the definition of primary graft dysfunction after lung transplantation. J Heart Lung Transplant. 2010 Nov;29(11):1231–9. PubMed PMID: 20655249. Pubmed Central PMCID: PMC2963709. Epub 2010/07/27. - PMC - PubMed
    1. Christie JD, Carby M, Bag R, et al. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part II: definition. A consensus statement of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2005 Oct;24(10):1454–9. PubMed PMID: 16210116. Epub 2005/10/08. - PubMed
    1. Christie JD, Kotloff RM, Ahya VN, et al. The effect of primary graft dysfunction on survival after lung transplantation. Am J Respir Crit Care Med. 2005 Jun 1;171(11):1312–6. PubMed PMID: 15764726. Pubmed Central PMCID: 2718464. - PMC - PubMed
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