Dietary intake of iron, zinc, copper, and risk of Parkinson's disease: a meta-analysis
- PMID: 26265293
- DOI: 10.1007/s10072-015-2349-0
Dietary intake of iron, zinc, copper, and risk of Parkinson's disease: a meta-analysis
Abstract
Although some studies have reported the associations between specific metal element intake and risk of Parkinson's disease (PD), the associations between specific metal element intake such as iron intake and PD are still conflicted. We aimed to determine whether intake of iron, zinc, and copper increases/decreases the risk of PD. PubMed, Embase, Web of Knowledge, and Google Scholar were searched. We pooled the multivariate-adjusted relative risks (RRs) or odds ratios using random effects. Study quality was evaluated by the Newcastle-Ottawa Scale. Five studies including 126,507 individuals remained for inclusion, pooled RRs of Parkinson's disease for moderate dietary iron intake was 1.08 (95 % CI 0.61-1.93, P = 0.787), and for high dietary iron intake was (1.03, 95 % CI 0.83-1.30, P = 0.766), respectively. The pooled RRs of Parkinson's disease for the highest compared with the lowest dietary iron intake were 1.47 (95 % CI 1.17-1.85, P = 0.001) in western population and in males (RR = 1.43, 95 % CI 1.01-2.01, P = 0.041). The pooled RRs of Parkinson's disease for moderate or high intake of zinc, and copper were not statistically different (P > 0.05). PD increased by 18 % (RR 1.18, 95 % CI 1.02-1.37) for western population by every 10-mg/day increment in iron intake. Higher iron intake appears to be not associated with overall PD risk, but may be associated with risk of PD in western population. Sex may be a factor influencing PD risk for higher iron intake. However, further studies are still needed to confirm the sex-selective effects.
Keywords: Copper; Diet; Iron; Meta-analysis; Parkinson’s disease; Zinc.
Similar articles
-
Dietary intake of metals and risk of Parkinson's disease: a case-control study in Japan.J Neurol Sci. 2011 Jul 15;306(1-2):98-102. doi: 10.1016/j.jns.2011.03.035. Epub 2011 Apr 16. J Neurol Sci. 2011. PMID: 21497832
-
Dietary iron, animal fats, and risk of Parkinson's disease.Mov Disord. 1998;13 Suppl 1:13-6. Mov Disord. 1998. PMID: 9613713
-
Dietary zinc and iron intake and risk of depression: A meta-analysis.Psychiatry Res. 2017 May;251:41-47. doi: 10.1016/j.psychres.2017.02.006. Epub 2017 Feb 3. Psychiatry Res. 2017. PMID: 28189077 Review.
-
Intakes of heme iron and zinc and colorectal cancer incidence: a meta-analysis of prospective studies.Cancer Causes Control. 2013 Jun;24(6):1175-83. doi: 10.1007/s10552-013-0197-x. Epub 2013 Apr 9. Cancer Causes Control. 2013. PMID: 23568532
-
Increased total iron and zinc intake and lower heme iron intake reduce the risk of esophageal cancer: A dose-response meta-analysis.Nutr Res. 2018 Nov;59:16-28. doi: 10.1016/j.nutres.2018.07.007. Epub 2018 Aug 3. Nutr Res. 2018. PMID: 30442229
Cited by
-
Zinc Intakes and Health Outcomes: An Umbrella Review.Front Nutr. 2022 Feb 8;9:798078. doi: 10.3389/fnut.2022.798078. eCollection 2022. Front Nutr. 2022. PMID: 35211497 Free PMC article. Review.
-
Dietary Copper Intake and Risk of Parkinson's Disease: a Cross-sectional Study.Biol Trace Elem Res. 2024 Mar;202(3):955-964. doi: 10.1007/s12011-023-03750-9. Epub 2023 Jul 18. Biol Trace Elem Res. 2024. PMID: 37462848 Free PMC article.
-
Dietary and Lifestyle Factors of Brain Iron Accumulation and Parkinson's Disease Risk.medRxiv [Preprint]. 2024 Mar 15:2024.03.13.24304253. doi: 10.1101/2024.03.13.24304253. medRxiv. 2024. PMID: 38559115 Free PMC article. Preprint.
-
Non-Genetic Risk Factors for Parkinson's Disease: An Overview of 46 Systematic Reviews.J Parkinsons Dis. 2021;11(3):919-935. doi: 10.3233/JPD-202521. J Parkinsons Dis. 2021. PMID: 33814465 Free PMC article. Review.
-
Parkinson's Disease and the Environment.Front Neurol. 2019 Mar 19;10:218. doi: 10.3389/fneur.2019.00218. eCollection 2019. Front Neurol. 2019. PMID: 30941085 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical