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Review
. 2015 Aug;8(4):167-71.
doi: 10.1007/s12328-015-0590-y. Epub 2015 Aug 12.

Future therapy for hepatitis B virus infection

Masahito Minami  1
Affiliations
Review

Future therapy for hepatitis B virus infection

Masahito Minami. Clin J Gastroenterol. 2015 Aug.

Abstract

We can now control hepatitis B virus infection by continuously administering nucleoside and nucleotide analogues such as entecavir and tenofovir. These drugs are generally safe and sufficiently effective, but future drugs are needed that can show off-treatment efficacy--in other words, eradication of latent hepatitis B virus DNA (covalently closed circular DNA) in the hepatocytes. This article is an overview of new drugs under development and some novel strategies to inhibit hepatitis B virus proliferation.

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