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Review
. 2015 Jun;9(6):ZE10-3.
doi: 10.7860/JCDR/2015/12872.6111. Epub 2015 Jun 1.

OPN -Revisited

Vijayanirmala Subraman  1 , Muthukumar Thiyagarajan  2 , N Malathi  3 , Sharada T Rajan  4
Affiliations
Review

OPN -Revisited

Vijayanirmala Subraman et al. J Clin Diagn Res. 2015 Jun.

Abstract

Osteopontin (OPN), a matrix extracellular glyco-phosphoprotein is found in various tissues such as epithelium lined tissues, kidney, bone and teeth .It is also detected in all body fluids including blood and breast milk. OPN plays role in a number of physiological and pathologic events such as cell adhesion, migration and cell survival, angiogenesis, apoptosis, inflammation and wound healing. This review summarizes the current data of the biological activities of OPN in the development of tumour, its progression and metastasis.

Keywords: Angiogenesis; Cell adhesion; Metastasis; Osteopontin.

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