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. 2014 Dec;2(1):3.
doi: 10.1186/2197-425X-2-3. Epub 2014 Feb 27.

Bis maltolato oxovanadium (BMOV) and ischemia/reperfusion-induced acute kidney injury in rats

Emre Almac  1 , Rick Bezemer, Asli Kandil, Ugur Aksu, Dan Mj Milstein, Jan Bakker, Cihan Demirci-Tansel, Can Ince
Affiliations

Bis maltolato oxovanadium (BMOV) and ischemia/reperfusion-induced acute kidney injury in rats

Emre Almac et al. Intensive Care Med Exp. 2014 Dec.

Abstract

Background: The aim of the present study was to test the potential protective effects of the organic vanadium salt bis (maltolato) oxovanadium (BMOV; 15 mg/kg) in the context of renal ischemia/reperfusion (30 min of ischemia) and its effects on renal oxygenation and renal function in the acute phase of reperfusion (up to 90 min post-ischemia).

Methods: Ischemia was established in anesthetized and mechanically ventilated male Wistar rats by renal artery clamping. Renal microvascular and venous oxygenation were measured using phosphorimetry. Creatinine clearance rate, sodium reabsorption, and renal oxygen handling efficiency were considered markers for renal function.

Results: The main findings were that BMOV did not affect the systemic and renal hemodynamic and oxygenation variables and partially protected renal sodium reabsorption.

Conclusions: Pretreatment with the organic vanadium compound BMOV did not protect the kidney from I/R injury.

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Figures

Figure 1
Figure 1
DO 2 and VO 2 (A), T Na+ (B), VO 2 / T Na+ (C), and CL crea (D) at the end of the protocol.
See this image and copyright information in PMC

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