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Comment
. 2015 Aug 13;524(7564):170-1.
doi: 10.1038/524170a.

Longevity: Mapping the path to a longer life

Morris F White  1
Affiliations
Comment

Longevity: Mapping the path to a longer life

Morris F White. Nature. .
No abstract available

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Figures

Fig. 1
Fig. 1
Insulin and insulin-like growth factor signalling (IIS) is triggered by binding of the insulin receptor (InsR) or insulin-like growth factor 1 receptor (IGF1R) and activation of an adaptor protein, which can be one of three or four IRS proteins in mammals or the Chico protein in Drosophila fruit flies. The pathway then splits into two main branches. One activates the proteins PI3K and AKT to cause inhibition of the transcription factor FOXO, an activator of gene transcription. The other branch activates the protein RAS, which then triggers a cascade involving RAF, MEK and ERK to inhibit the transcription factor ETV6 (or its equivalent in flies, AOP), a repressor of gene transcription. Slack et al. show that, in Drosophila, mutating chico to disrupt either of these pathways, or inhibiting the RAS–ERK pathway by treating flies with the MEK inhibitor trametinib, leads to extended lifespan. Adapted from ref. (CC BY 4.0).
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References

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