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Review
. 2015;7(8):899-911.
doi: 10.2217/IMT.15.54. Epub 2015 Aug 13.

Update on CD40 and CD154 blockade in transplant models

Tianshu Zhang  1 , Richard N Pierson 3rd  1   2 , Agnes M Azimzadeh  1
Affiliations
Review

Update on CD40 and CD154 blockade in transplant models

Tianshu Zhang et al. Immunotherapy. 2015.

Abstract

Generation of an effective immune response against foreign antigens requires two distinct molecular signals: a primary signal provided by the binding of antigen-specific T-cell receptor to peptide-MHC on antigen-presenting cells and a secondary signal delivered via the engagement of costimulatory molecules. Among various costimulatory signaling pathways, the interactions between CD40 and its ligand CD154 have been extensively investigated given their essential roles in the modulation of adaptive immunity. Here, we review current understanding of the role CD40/CD154 costimulation pathway has in alloimmunity, and summarize recent mechanistic and preclinical advances in the evaluation of candidate therapeutic approaches to target this receptor-ligand pair in transplantation.

Keywords: CD40/CD154; T cells; alloimmunity; costimulation; tolerance; transplantation.

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Figures

Figure 1
Figure 1. Role of CD40/CD154 in T-cell activation
Signaling following CD40/CD154 interactions promotes CD28-mediated costimulation by upregulating B7–1 and B7–2 expression on antigen-presenting cells and enhances T-cell activation by augmenting the potency of antigen-presenting cells to present antigen. In addition, CD28 engagement on T cells upregulates CD154 (CD40L) expression. +: positive (activating) costimulatory signal; −: negative (inhibitory) signal.
See this image and copyright information in PMC

References

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