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Controlled Clinical Trial
. 2015 Aug 14:14:105.
doi: 10.1186/s12933-015-0267-3.

Long-term effects of the multidisciplinary risk assessment and management program for patients with diabetes mellitus (RAMP-DM): a population-based cohort study

Fangfang Jiao  1 , Colman Siu Cheung Fung  2 , Yuk Fai Wan  3 , Sarah Morag McGhee  4 , Carlos King Ho Wong  5 , Daisy Dai  6 , Ruby Kwok  7 , Cindy Lo Kuen Lam  8
Affiliations
Controlled Clinical Trial

Long-term effects of the multidisciplinary risk assessment and management program for patients with diabetes mellitus (RAMP-DM): a population-based cohort study

Fangfang Jiao et al. Cardiovasc Diabetol. .

Abstract

Background: Studies on the long-term effectiveness of multidisciplinary risk-stratification based management in Chinese population were rare. This study aimed to evaluate the effectiveness of a multidisciplinary risk assessment and management program for patients with diabetes mellitus (RAMP-DM) in reducing the risks of cardiovascular complications and all-cause mortality.

Methods: A prospective cohort study was conducted in 18,188 propensity score matched RAMP-DM participants and subjects with diabetes under usual primary care (9,094 subjects in each group). The study endpoints were the first occurrence of coronary heart disease (CHD), stroke, heart failure (HF), total cardiovascular disease (CVD) and all-cause mortality. We constructed multivariable Cox proportional hazard regressions to estimate the association between the RAMP-DM intervention and the first occurrence of study endpoints.

Results: The median follow-up period was 36 months. Three hundred and ninety-nine CVD events occurred in the RAMP-DM group, as compared with 608 in the control group [adjusted hazard ratio, 0.629; 95% confidence interval (CI) 0.554-0.715; P < 0.001]. The total number of all-cause deaths in RAMP-DM group was less than half that of control group (202 vs 552, adjusted hazard ratio, 0.363; 95% CI, 0.308-0.428; P < 0.001). The adjusted hazard ratios of the RAMP-DM group for CHD, stroke, and HF were 0.570 (95% CI, 0.470-0.691; P < 0.001), 0.652 (95% CI, 0.546-0.780; P < 0.001), and 0.598 (95%CI, 0.446-0.802; P = 0.001), respectively.

Conclusions: The RAMP-DM intervention was associated with lower incidences of individual and total cardiovascular complications, as well as all-cause mortality over 3 years follow-up. The encouraging results provided evidence to support that the structured risk-stratification management leading by a multidisciplinary clinical team was an effective approach to reduce future cardiovascular complications in people with diabetes.

Clinical trial registry: NCT02034695, http://www.ClinicalTrials.gov.

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Figures

Fig. 1
Fig. 1
Flow chart of subjects matching. RAMP-DM risk assessment and management programme for patients with diabetes mellitus.
Fig. 2
Fig. 2
Kaplan-Meier survival curves. CVD cardiovascular diseases and CHD coronary heart disease.
See this image and copyright information in PMC

References

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