Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989:258:229-34.
doi: 10.1007/978-1-4613-0537-8_20.

Bioavailable copper complexes offer a physiologic approach to treatment of chronic diseases

J R Sorenson  1 , L S Soderberg, M V Chidambaram, D T de la Rosa, H Salari, K Bond, G L Kearns, R A Gray, C E Epperson, M L Baker
Affiliations

Bioavailable copper complexes offer a physiologic approach to treatment of chronic diseases

J R Sorenson et al. Adv Exp Med Biol. 1989.

Abstract

Copper (II)2(3,5-Diisopropylsalicylate)4(H2O)2 has been found to have antiinflammatory, antiulcer, anticonvulsant, anticancer, anticarcinogenic, antimutagenic, and radiation recovery activities and it prevents reperfusion injury. To study pharmacokinetic parameters accounting for these pharmacological effects the double labeled 67Cu(II)2(carboxy-14C-3,5-diisopropylsalicylate)4 complex was synthesized and used to obtain these parameters. Treatment of mice with 1 mumol of this complex revealed that 67Cu was distributed to blood, liver, kidney, intestine, lung, thymus, femur, muscle, spleen, brain, urine, and feces within 0.5 hr and patterned changes in 67Cu content of these tissues and excreta were found throughout the 96 hr term of this study.

PubMed Disclaimer

Publication types