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Comment
. 2015 Aug 12;18(2):133-4.
doi: 10.1016/j.chom.2015.07.009.

Dengue Non-coding RNA: TRIMmed for Transmission

Giel P Göertz  1 , Gorben P Pijlman  2
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Dengue Non-coding RNA: TRIMmed for Transmission

Giel P Göertz et al. Cell Host Microbe. .
Free article

Abstract

Dengue virus RNA is trimmed by the 5'→3' exoribonuclease XRN1 to produce an abundant, non-coding subgenomic flavivirus RNA (sfRNA) in infected cells. In a recent paper in Science, Manokaran et al. (2015) report that sfRNA binds TRIM25 to evade innate immune sensing of viral RNA by RIG-I.

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