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. 2015 Aug 12;18(2):144-6.
doi: 10.1016/j.chom.2015.07.011.

Do You Believe in ReincaRNAtion? Herpesviruses Reveal Connection between RNA Decay and Synthesis

Joseph Russo  1 , Jeffrey Wilusz  2
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Do You Believe in ReincaRNAtion? Herpesviruses Reveal Connection between RNA Decay and Synthesis

Joseph Russo et al. Cell Host Microbe. .
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Abstract

Many viruses degrade host mRNAs to reduce competition for proteins/ribosomes and promote viral gene expression. In this issue of Cell Host & Microbe, Abernathy et al. (2015) demonstrate that a herpesviral RNA endonuclease induces host transcriptional repression that is mediated through the decay factor Xrn1 and evaded by viral genes.

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