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. 2015 Sep;35(9):569-74.
doi: 10.1007/s40261-015-0313-7.

Effect of inhaled corticosteroids on salival composition: a cross-sectional study in patients with bronchial asthma

Bernardino Alcázar Navarrete  1 , Pedro José Romero Palacios, Antonio Aguilar-Salvatierra, Javier Guardia, Gerardo Gómez-Moreno
Affiliations

Effect of inhaled corticosteroids on salival composition: a cross-sectional study in patients with bronchial asthma

Bernardino Alcázar Navarrete et al. Clin Drug Investig. 2015 Sep.

Abstract

Background: To date, no evidence exists in the literature as to the effects of inhaled corticosteroids (ICs) on salivary composition in patients with bronchial asthma.

Objective: The aim of this study was to assess the effect of ICs on salival composition.

Methods: Adult patients attending an outpatient respiratory clinic who were classified into two groups (controls and patients with bronchial asthma receiving ICs), were recruited in this cross-sectional study. For each participant, data of clinical records, baseline history of asthma, and regular IC dose were recorded. A sample of stimulated saliva was collected and processed for investigation of mucin 5B (MUC5B), lipoxygenase (LPO), total antioxidant capacity, and 8-hydroxydeoxyguanosine (8-OHdG) levels.

Results: Overall, 103 patients (49 controls and 54 patients receiving regular treatment with ICs) were recruited. No differences in comorbidities or smoking habits were observed. Patients treated with high-doses of ICs showed lower levels of salival MUC5B compared with those treated with medium IC doses or those not treated with ICs (1.60 vs. 2.20 vs. 2.53 ng/mL; p = 0.042).

Conclusion: In patients with asthma, treatment with high-doses of ICs is associated with reduced levels of salivary MUC5B. This effect can explain some of the effects of ICs on oral health.

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