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. 2015 Sep-Oct;19(5):450-6.
doi: 10.1177/1203475415586332. Epub 2015 May 7.

The Relationship of Obesity With the Severity of Psoriasis: A Systematic Review

Patrick Fleming  1 , John Kraft  2 , Wayne P Gulliver  3 , Charles Lynde  4
Affiliations

The Relationship of Obesity With the Severity of Psoriasis: A Systematic Review

Patrick Fleming et al. J Cutan Med Surg. 2015 Sep-Oct.

Abstract

Background: Psoriasis is a chronic inflammatory disease associated with obesity. The increased production of adipocytokines in central adiposity contributes to the systemic inflammation of obesity and perhaps to psoriasis.

Objective: The objective of this systematic review is to determine the association of obesity with psoriasis severity.

Methods: We searched PubMed, EMBASE, and Cochrane Database for English-language papers involving human subjects for all years. We extracted data on age, sex, body mass index (BMI), proportion obese, and psoriasis severity index score (PASI).

Results: We identified 254 articles in our search and included 9. The sample size was 134 823 psoriasis patients. Seven of the 9 studies found a statistically significant association of increased psoriasis severity with higher BMI.

Conclusion: Increased severity of psoriasis appears to be associated with increased BMI. Most studies were cross-sectional or case-control, making it difficult to determine temporality. Dermatologists should consider recording BMI for psoriasis patients and offering them lifestyle counseling.

Keywords: obesity; psoriasis.

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