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. 2015 Nov;100(11):e434-7.
doi: 10.3324/haematol.2015.130112. Epub 2015 Aug 13.

Genomic patterns associated with hypoplastic compared to hyperplastic myelodysplastic syndromes

Aziz Nazha  1 , David Seastone  1 , Tom Radivoyevitch  2 , Bartlomiej Przychodzen  2 , Hetty E Carraway  1 , Bhumika J Patel  2 , Jennifer Carew  2 , Hideki Makishima  2 , Mikkael A Sekeres  1 , Jaroslaw P Maciejewski  3
Affiliations

Genomic patterns associated with hypoplastic compared to hyperplastic myelodysplastic syndromes

Aziz Nazha et al. Haematologica. 2015 Nov.
No abstract available

Keywords: MDS; hypoplastic; mutations.

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Figures

Figure 1.
Figure 1.
Frequency of gene mutations involved in common functional pathways. Genes included in common functional pathways: Splicing: SF3B1, SRSF2, ZRSR2, U2AF1/2. DNA methylation: TET2, DNMT3A, IDH1/2. Transcription: SETBP1, RUNX1, BCOR/BCORL1, ETV6, NPM1, CEBPA, GATA2. Chromatin Modification: ASXL1, SUZ12, EZH2, MLL, KDM6A. Receptor/Kinases: JAK2, FLT3, KIT. Cohesion: STAG2, SMC3, SIMC1, RAD21. RAS Pathway: KRAS/NRAS, CBL, NF1, PTPN11. RNA Helicase: DDX41, DDX54, DHX29. Tumor Suppressor: TP53, APC, WT1, PFH6.
Figure 2.
Figure 2.
Distribution of mutations of significantly mutated genes in hypo-MDS vs. hyper-MDS.
Figure 3.
Figure 3.
Distribution of driver clones in hypo-MDS vs. hyper-MDS.
See this image and copyright information in PMC

References

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