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Meta-Analysis
. 2015:2015:213737.
doi: 10.1155/2015/213737. Epub 2015 Jul 26.

Association of Nonalcoholic Fatty Liver Disease with Subclinical Cardiovascular Changes: A Systematic Review and Meta-Analysis

Enea Bonci  1 , Claudio Chiesa  2 , Paolo Versacci  3 , Caterina Anania  3 , Lucia Silvestri  3 , Lucia Pacifico  3
Affiliations
Meta-Analysis

Association of Nonalcoholic Fatty Liver Disease with Subclinical Cardiovascular Changes: A Systematic Review and Meta-Analysis

Enea Bonci et al. Biomed Res Int. 2015.

Abstract

In the last 20 years, nonalcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide, primarily as a result of the epidemic of obesity. NAFLD is strongly associated with insulin resistance, glucose intolerance, and dyslipidemia and is currently regarded as the liver manifestation of the metabolic syndrome, a highly atherogenic condition even at a very early age. Patients with NAFLD including pediatric subjects have a higher prevalence of subclinical atherosclerosis, as shown by impaired flow-mediated vasodilation, increased carotid artery intima-media thickness, and arterial stiffness, which are independent of obesity and other established risk factors. More recent work has identified NAFLD as a risk factor not only for premature coronary heart disease and cardiovascular events, but also for early subclinical abnormalities in myocardial structure and function. Thus, we conducted a systematic review and meta-analysis to test the hypothesis that NAFLD is associated with evidence of subclinical cardiac structural and functional abnormalities.

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Figures

Figure 1
Figure 1
Schematic flow chart for the selection of studies.
Figure 2
Figure 2
Forest plots show the comparison of LV mass indexed to BSA between NAFLD patients and NO NAFLD subjects.
Figure 3
Figure 3
Forest plots show the comparison of early mitral velocity (E)/late mitral velocity (A) ratio between NAFLD patients and NO NAFLD subjects.
Figure 4
Figure 4
Forest plots show the comparison of E/early diastolic tissue velocity (e′) ratio between NAFLD patients and NO NAFLD subjects.
Figure 5
Figure 5
Forest plots show the comparison of LV mass indexed to height2.7 between NAFLD and NO NAFLD obese children and adolescents (a) and between obese children with NAFLD and healthy lean subjects (b).
Figure 6
Figure 6
Forest plots show the comparison of early mitral velocity (E)/late mitral velocity (A) ratio between NAFLD and NO NAFLD obese children and adolescents.
Figure 7
Figure 7
Forest plots show the comparison of E/early diastolic tissue velocity (e′) ratio between NAFLD and NO NAFLD obese children and adolescents.
See this image and copyright information in PMC

References

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